Pharmacodynamics: PET power

Pharmacokinetics/ Pharmacodynamics

Pharmacodynamics of antimicrobial drugs.

Knowledge of the antimicrobial pharmacodynamic characteristics of a drug (inhibition of growth, rate and extent of bactericidal action, and postantibiotic effect) provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval. This article reviews concepts of antimicrobial pharmacodynamics, the effect of pharmacodynamics on the emergence...

Topiramate: pharmacokinetics and pharmacodynamics.

Topiramate is a structurally novel anti-epileptic drug with at least 3 postulated mechanisms of action including: 1) potentiation of GABA responses, 2) impairment of AMPA/kainate glutamate receptors and 3) suppression of high frequency action potential firing. It has a favourable pharmacokinetic profile with rapid absorption, good bio-availability, linear pharmacokinetics, relatively long half-...

Systems Pharmacology and Pharmacodynamics

Reviewed by Piet H. van der Graaf In 2008 and 2010, the National Institute of General Medical Sciences of the National Institutes of Health sponsored two workshops that resulted in the 2011 white paper “Quantitative and Systems Pharmacology in the Post-genomic Era: New Approaches to Discovering Drugs and Understanding Therapeutic Mechanisms,” which is widely accepted to be a milestone marking t...

4D PET: Beyond conventional dynamic PET imaging

  In this paper, we review novel techniques in the emerging field of spatiotemporal 4D PET imaging. We will discuss existing limitations in conventional dynamic PET imaging which involves independent reconstruction of dynamic PET datasets. Various approaches that seek to attempt some or all of these limitations are reviewed in this work, including techniques that util...